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Phytonadione
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Properties
Product Name Phytonadione
Cas Number 84-80-0
Formula C31H46O2
Molar Mass 450.70 g/mol
Pub Chem Cid 5284607
Drug Bank DB01022
Chem Spider 4445375
Bioavailability Variable
Protein Binding Approximately 99.9%
Metabolism Hepatic
Elimination Halflife 22.5 hours
FAQ
What is Phytonadione?

Phytonadione, also known as vitamin K1, is a fat-soluble vitamin that plays a crucial role in blood clotting. It is essential for the synthesis of clotting factors in the liver, which are necessary for the proper coagulation of blood.

How does Phytonadione work in the body?

When there is an injury that results in bleeding, the body needs to form a blood clot to stop the bleeding. Phytonadione helps in this process by ensuring that the liver produces enough clotting factors, specifically prothrombin (factor II) and other vitamin K-dependent clotting proteins. These proteins work together to form a blood clot and prevent excessive bleeding.

What are the common uses of Phytonadione?

Phytonadione is commonly used to treat and prevent bleeding disorders, such as vitamin K deficiency, which can be caused by conditions like liver disease, malabsorption disorders, or the long-term use of certain medications like antibiotics. It is also given to newborns to prevent a rare bleeding disorder known as vitamin K deficiency bleeding.

What are the possible side effects of Phytonadione?

While Phytonadione is generally considered safe when used as directed, there are some potential side effects that may occur. These include redness, swelling, or pain at the injection site, allergic reactions, and rarely, anaphylaxis. It is important to seek medical attention if you experience any unusual or severe side effects after taking Phytonadione.

How should Phytonadione be taken?

Phytonadione is typically administered by injection either into a muscle or a vein, depending on the specific situation. The dosage and frequency of administration will vary based on the individual's condition and needs. It is important to follow the instructions provided by your healthcare provider or pharmacist and not to self-administer Phytonadione without proper guidance.

Are there any interactions with other medications?

Phytonadione can interact with certain medications, such as anticoagulants (blood thinners) like warfarin, which work by inhibiting the action of vitamin K. Taking Phytonadione with these medications can interfere with their effectiveness and lead to serious consequences. It is essential to inform your healthcare provider about all the medications you are taking before starting Phytonadione therapy.

Is Phytonadione safe for pregnant or breastfeeding women?

Phytonadione is generally considered safe for use during pregnancy and breastfeeding when prescribed by a healthcare provider. Adequate levels of vitamin K are important for the proper development of the baby's blood clotting system. However, it is essential to consult with a healthcare professional before starting any new medication during pregnancy or while breastfeeding.

Can Phytonadione be used in children?

Yes, Phytonadione can be safely used in children, including newborns. In fact, newborns are routinely given a dose of Phytonadione shortly after birth to prevent vitamin K deficiency bleeding, which can be life-threatening. The dosage for children will be based on their age, weight, and medical condition, as determined by a healthcare provider.

What should I do if I miss a dose of Phytonadione?

If you miss a dose of Phytonadione, contact your healthcare provider for guidance on when to take the next dose. It is essential not to double up on doses to make up for a missed one, as this can increase the risk of side effects or complications. Consistent and timely administration of Phytonadione is crucial for its effectiveness in managing bleeding disorders.

How should Phytonadione be stored?

Phytonadione should be stored at room temperature away from light and moisture. It should be kept out of reach of children and pets to prevent accidental ingestion. Do not freeze Phytonadione, and discard any unused or expired medication properly according to the instructions provided by your healthcare provider or pharmacist.
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